Deciphering the complex interplay between microbiota, HPV, inflammation and cancer through cervicovaginal metabolic profiling

2019301 citationsJournal Articlegold Open Access

Authors

Zehra Esra Ilhan · University of Arizona

Paweł Łaniewski · University of Arizona

Natalie Thomas · University of Arizona

Denise J. Roe · University of Arizona

Dana M. Chase · St. Joseph's Hospital and Medical Center

Melissa M. Herbst‐Kralovetz · University of Arizona

Abstract

Cervicovaginal metabolic profiles were driven by cancer followed by genital inflammation, HPV infection, and vaginal microbiota. This study provides evidence for metabolite-driven complex host-microbe interactions as hallmarks of cervical cancer with future translational potential. FUND: Flinn Foundation (#1974), Banner Foundation Obstetrics/Gynecology, and NIH NCI (P30-CA023074).

Topics & Keywords

Cervical Cancer and HPV Research Metabolomics and Mass Spectrometry Studies Gut microbiota and health

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: EBioMedicine

Volume 44, pp. 675-690

DOI: 10.1016/j.ebiom.2019.04.028

Field-Weighted Citation Impact: 18.22