Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data

2019134 citationsJournal Articlegold Open Access

Authors

Hao Yang · University of Shanghai for Science and Technology

Daixi Li · University of Shanghai for Science and Technology

Yong Xu · Shanghai Academy of Science & Technology

Jian Ouyang · Shanghai Center For Bioinformation Technology

Yongkun Wang · Shanghai Academy of Science & Technology

Yuqi Zhang · University of Shanghai for Science and Technology

Baoguo Li

Abstract

Our study provides an integrated analysis of lipid metabolism in pan-cancer, highlights the perturbation of key metabolism processes in tumorigenesis and clarificates the regulation mechanism of abnormal lipid metabolism and effects of lipid metabolism on tumor immune microenvironment. This study also provides new clues for biomarkers or therapeutic targets of lipid metabolism in tumors.

Topics & Keywords

Cancer, Lipids, and Metabolism Ferroptosis and cancer prognosis Metabolomics and Mass Spectrometry Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Bioinformatics

Volume 20, Issue S7, pp. 195-195

DOI: 10.1186/s12859-019-2734-4

Field-Weighted Citation Impact: 4.59