miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells

2019114 citationsJournal Articlegold Open Access

Authors

Mahrou Vahabi · University of Tehran

Claudio Pulito · Istituti di Ricovero e Cura a Carattere Scientifico

Andrea Sacconi · Istituti di Ricovero e Cura a Carattere Scientifico

Sara Donzelli · Istituti di Ricovero e Cura a Carattere Scientifico

M. D’Andrea · Istituti di Ricovero e Cura a Carattere Scientifico

Valentina Manciocco · Istituti di Ricovero e Cura a Carattere Scientifico

Abstract

These results highlight a new mechanism of chemo/radio-resistance insurgence in HNSCC cells and support the possibility that miR-96-5p expression could be used as a novel promising biomarker to predict radiotherapy response and local recurrence development in HNSCC patients. In addition, the identification of pathways in which miR-96-5p is involved could contribute to develop new therapeutic strategies to overcome radio-resistance.

Topics & Keywords

MicroRNA in disease regulation Cancer-related molecular mechanisms research RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Experimental & Clinical Cancer Research

Volume 38, Issue 1, pp. 141-141

DOI: 10.1186/s13046-019-1119-x

Field-Weighted Citation Impact: 4.28