ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach

20191,031 citationsReviewhybrid Open Access

Authors

Claudio Luchini · University of Verona

Frédéric Bibeau · Université de Caen Normandie

M. Ligtenberg · Radboud University Nijmegen

Naveena Singh · Barts Health NHS Trust

Alessia Nottegar · Ospedale San Bortolo

Tjalling Bosse · Leiden University

Robert E. Miller ·

Abstract

This ESMO initiative is a response to the urgent questions raised by the growing success of immunotherapy and provides also important insights on the relationships between MSI, TMB and PD-1/PD-L1.

Topics & Keywords

Genetic factors in colorectal cancer Cancer Genomics and Diagnostics Lung Cancer Treatments and Mutations

UN Sustainable Development Goals

Partnerships for the goals

Publication Details

Published in: Annals of Oncology

Volume 30, Issue 8, pp. 1232-1243

DOI: 10.1093/annonc/mdz116

Field-Weighted Citation Impact: 69.93