CSF chitinase proteins in amyotrophic lateral sclerosis

2019104 citationsJournal Article

Authors

Alexander G. Thompson · University of Oxford

Elizabeth Gray · University of Oxford

Alexander Bampton · University of Oxford

Dominika Raciborska · Queen Mary University of London

Kevin Talbot · University of Oxford

Martin R. Turner · University of Oxford

Abstract

CSF chitinase proteins may have limited value as independent diagnostic and stratification biomarkers in ALS, but offer a window into non-autonomous mechanisms of motor neuronal loss in ALS, specifically in assessing response to therapies targeting neuroinflammatory pathways.

Topics & Keywords

Amyotrophic Lateral Sclerosis Research Neurogenetic and Muscular Disorders Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neurology Neurosurgery & Psychiatry

Volume 90, Issue 11, pp. 1215-1220

DOI: 10.1136/jnnp-2019-320442

Field-Weighted Citation Impact: 6.89