Rapid Clearance Profile of Plasma Circulating Tumor HPV Type 16 DNA during Chemoradiotherapy Correlates with Disease Control in HPV-Associated Oropharyngeal Cancer

2019316 citationsJournal Articlegreen Open Access

Authors

Bhishamjit S. Chera · University of North Carolina at Chapel Hill

Sunil Kumar · University of North Carolina at Chapel Hill

Brian T. Beaty · University of North Carolina at Chapel Hill

David Marron · University of North Carolina at Chapel Hill

Stuart R. Jefferys · University of North Carolina at Chapel Hill

Rebecca Green · University of North Carolina at Chapel Hill

Emily C. Goldman

Abstract

A rapid clearance profile of ctHPVDNA may predict likelihood of disease control in patients with HPV-associated OPSCC patients treated with definitive CRT and may be useful in selecting patients for deintensified therapy.

Topics & Keywords

Head and Neck Cancer Studies Cancer Genomics and Diagnostics Cervical Cancer and HPV Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 25, Issue 15, pp. 4682-4690

DOI: 10.1158/1078-0432.ccr-19-0211

Field-Weighted Citation Impact: 22.96