Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway

2019144 citationsJournal Articlegold Open Access

Authors

Guanghui Lian · Central South University

Shuijiao Chen · Central South University

Miao Ouyang · Xiangya Hospital Central South University

Fujun Li · Xiangya Hospital Central South University

Linlin Chen · Xiangya Hospital Central South University

Junwen Yang · Central South University

Abstract

We provide evidence that EGF which are secreted by colon cancer cells play contributory role in M2 polarization of macrophages, which support the notion that tumor environment, including tumor-associated macrophages, can be targeted to develop effective strategies for treating cancer.

Topics & Keywords

Immune cells in cancer Cancer Cells and Metastasis Cancer, Stress, Anesthesia, and Immune Response

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Technology in Cancer Research & Treatment

Volume 18, pp. 1533033819849068-1533033819849068

DOI: 10.1177/1533033819849068

Field-Weighted Citation Impact: 5.74