Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

2019175 citationsJournal Articlegold Open Access

Authors

Yu Zheng · Affiliated Hospital of Jiangsu University

Xinyu Tian · Affiliated Hospital of Jiangsu University

Tingting Wang · Nanjing Medical University

Xueli Xia · Jiangsu University

Fenghua Cao

Jie Tian · Jiangsu University

Ping Xu · The Fifth People’s Hospital of Suzhou

Abstract

Taken together, our results demonstrate a critical role for lncRNA Pvt1 in regulating the immunosuppression activity of G-MDSCs, and lncRNA Pvt1 might thus be a potential antitumor immunotherapy target.

Topics & Keywords

Immune cells in cancer Cancer-related molecular mechanisms research Immune Cell Function and Interaction

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Cancer

Volume 18, Issue 1, pp. 61-61

DOI: 10.1186/s12943-019-0978-2

Field-Weighted Citation Impact: 11.80