Multinational comparison of new antidepressant use in older adults: a cohort study

201974 citationsJournal Articlegold Open Access

Authors

Robyn Tamblyn · McGill University

David W. Bates · Brigham and Women's Hospital

David L. Buckeridge · Sante Montreal

William G Dixon · University of Manchester

Alan J. Forster · Ottawa Hospital

Nadyne Girard · McGill University

Jennifer S. Haas ·

Abstract

Antidepressant use in older adults varied 24-fold by country, with the UK, which has the most conservative treatment guidelines, being among the lowest. Chronic pain was the most common potential treatment indication. Evaluation of real-world risks of TCAs is a priority for future research, given high rates of use and the potential for increased toxicity in older adults because of potent anticholinergic effects.

Topics & Keywords

Treatment of Major Depression Pharmaceutical Practices and Patient Outcomes Schizophrenia research and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMJ Open

Volume 9, Issue 5, pp. e027663-e027663

DOI: 10.1136/bmjopen-2018-027663

Field-Weighted Citation Impact: 4.28