An enrichment method to increase cell-free fetal DNA fraction and significantly reduce false negatives and test failures for non-invasive prenatal screening: a feasibility study

201970 citationsJournal Articlegold Open Access

Authors

Ping Hu · Nanjing Medical University

Liang Dong · Nanjing Maternity and Child Health Care Hospital

Yangyi Chen · Sinotech Genomics (China)

Ying Lin · Nanjing Maternity and Child Health Care Hospital

Fengchang Qiao · Nanjing Maternity and Child Health Care Hospital

Hang Li · Nanjing Medical University

Ting Wang

Abstract

We developed an effective method to enrich cffDNA for NIPS, which shows an increased success rate and a reduced chance of false negative comparing to the ordinary NIPS method.

Topics & Keywords

Prenatal Screening and Diagnostics Fetal and Pediatric Neurological Disorders Cancer Genomics and Diagnostics

Publication Details

Published in: Journal of Translational Medicine

Volume 17, Issue 1, pp. 124-124

DOI: 10.1186/s12967-019-1871-x

Field-Weighted Citation Impact: 16.04

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An enrichment method to increase cell-free fetal DNA fraction and significantly reduce false negatives and test failures for non-invasive prenatal screening: a feasibility study

Authors

Abstract

Topics & Keywords

Publication Details