IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury

201965 citationsJournal Articlegold Open Access

Authors

Kyan James Allahdadi · Hospital São Rafael

Thaís Alves de Santana · Hospital São Rafael

Girlaine Café Santos · Universidade Federal da Bahia

Carine Machado Azevedo · Fundação Oswaldo Cruz

Roberta Alves Mota · Universidade Federal da Bahia

Carolina Kymie Vasques Nonaka · Hospital São Rafael

Daniela Nascimento Silva

Abstract

Overexpression of IGF-1 in BMMSC resulted in increased cell survival, immunomodulation, myelination, and functional improvements, suggesting that IGF-1 facilitates the regenerative actions of BMMSC in acute SCI.

Topics & Keywords

Spinal Cord Injury Research Mesenchymal stem cell research Spinal Dysraphism and Malformations

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

Volume 10, Issue 1, pp. 146-146

DOI: 10.1186/s13287-019-1223-z

Field-Weighted Citation Impact: 5.53