Microbiological Profile of Ozenoxacin

<b>Aim:</b> To explore the antibacterial spectrum of ozenoxacin and compare its <i>in vitro</i> activity with that of other antibacterial agents. <b>Materials & methods:</b> In 2010, 10,054 isolates were collected from 128 centers worldwide. Minimum inhibitory concentrations against Gram-positive and Gram-negative isolates were determined for 23 and 13 antibacterial agents, respectively. <b>Results:</b> Ozenoxacin exhibited high <i>in vitro</i> activity against susceptible, and methicillin- or levofloxacin-resistant, Gram-positive bacteria. Ozenoxacin was one or two dilutions less active against Enterobacteriaceae isolates, except for <i>Escherichia coli</i>, than other quinolones. <b>Conclusion:</b> Ozenoxacin is a potent antimicrobial agent mainly against susceptible and resistant strains of Gram-positive isolates (staphylococci and streptococci), and shows activity against some Gram-negative isolates.