Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium

201923 citationsJournal Articlegold Open Access

Authors

Shotaro Takano · Kitasato University

Kentaro Uchida · Kitasato University

Makoto Itakura · Kitasato University

Dai Iwase · Kitasato University

Jun Aikawa · Kitasato University

Gen Inoue · Kitasato University

Manabu Mukai · Kitasato University

Abstract

TGF-β regulates NGF production via the TGF-β/ALK5 signaling pathway in osteoarthritic synovium. This effect may partially occur through inhibition of the TAK1/p38 pathway in the SYT of KOA patients.

Topics & Keywords

Osteoarthritis Treatment and Mechanisms Tendon Structure and Treatment Spine and Intervertebral Disc Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Musculoskeletal Disorders

Volume 20, Issue 1, pp. 204-204

DOI: 10.1186/s12891-019-2595-z

Field-Weighted Citation Impact: 2.76