Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage

201978 citationsJournal Articlegold Open Access

Authors

Svetlana Lublinsky · Ben-Gurion University of the Negev

Sebastian Major · Charité - Universitätsmedizin Berlin

Vasilis Kola · Charité - Universitätsmedizin Berlin

Viktor Horst · Charité - Universitätsmedizin Berlin

Edgar Santos · Heidelberg University

Johannes Platz · Goethe University Frankfurt

Oliver Sakowitz

Abstract

We suggest that early identification of BBBD may serve as a key predictive biomarker for neurological outcome in aSAH. FUND: Dr. Dreier was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) (DFG DR 323/5-1 and DFG DR 323/10-1), the Bundesministerium für Bildung und Forschung (BMBF) Center for Stroke Research Berlin 01 EO 0801 and FP7 no 602150 CENTER-TBI. Dr. Friedman was supported by grants from Israel Science Foundation and Canada Institute for Health Research (CIHR). Dr. Friedman was supported by grants from European Union's Seventh Framework Program (FP7/2007-2013; grant #602102).

Topics & Keywords

Intracranial Aneurysms: Treatment and Complications Traumatic Brain Injury and Neurovascular Disturbances Cerebrospinal fluid and hydrocephalus

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: EBioMedicine

Volume 43, pp. 460-472

DOI: 10.1016/j.ebiom.2019.04.054

Field-Weighted Citation Impact: 6.89