Synthesis of Isoxazoles via Electrophilic Cyclization

2005223 citationsJournal Article

Authors

Richard C. Larock · Iowa State University

Abstract

[reaction: see text] A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICl, I2, Br2, or PhSeBr.

Topics & Keywords

Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods Synthesis and Catalytic Reactions

Publication Details

Published in: Organic Letters

Volume 7, Issue 23, pp. 5203-5205

DOI: 10.1021/ol052027z

Field-Weighted Citation Impact: 4.04

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Synthesis of Isoxazoles via Electrophilic Cyclization

Authors

Abstract

Topics & Keywords

Publication Details