Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition

2019119 citationsJournal Articlehybrid Open Access

Authors

Ganna Leonenko · Cardiff Council

Maryam Shoai · UK Dementia Research Institute

Eftychia Bellou · Cardiff Council

Rebecca Sims · Cardiff Council

Julie Williams · Cardiff Council

John Hardy · UK Dementia Research Institute

Valentina Escott‐Price ·

Abstract

The results showed different pattern of APOE contribution in PRS risk predictions of AD/MCI and amyloid deposition. Our study suggests that APOE mostly contributes to amyloid accumulation and the PRS affects risk of further conversion to AD. ANN NEUROL 2019;86:427-435.

Topics & Keywords

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Genetic Associations and Epidemiology

Publication Details

Published in: Annals of Neurology

Volume 86, Issue 3, pp. 427-435

DOI: 10.1002/ana.25530

Field-Weighted Citation Impact: 8.35

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Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition

Authors

Abstract

Topics & Keywords

Publication Details