Neuropilin-1 drives tumor-specific uptake of chlorotoxin

201919 citationsJournal Articlegold Open Access

Authors

Sharon McGonigle · Eisai (United States)

Utpal Majumder · Eisai (United States)

Donna Kolber‐Simonds · Eisai (United States)

Jiayi Wu · Eisai (United States)

Andrew Hart · Eisai (United States)

Thomas A. Noland · Eisai (United States)

Karen TenDyke ·

Abstract

NRP1 was identified as a novel Cltx target which enhances tumor drug uptake. This finding should facilitate tumor selection for chlorotoxin-based therapeutics and diagnostics.

Topics & Keywords

Angiogenesis and VEGF in Cancer Cancer, Hypoxia, and Metabolism Receptor Mechanisms and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cell Communication and Signaling

Volume 17, Issue 1, pp. 67-67

DOI: 10.1186/s12964-019-0368-9

Field-Weighted Citation Impact: 0.77