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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

20191,548 citationsJournal Article

Authors

Omar Khan · Parker Institute for Cancer Immunotherapy

Josephine R. Giles · University of Pennsylvania

Sierra McDonald · University of Pennsylvania

Sasikanth Manne · Translational Therapeutics (United States)

Shin Foong Ngiow · University of Pennsylvania

Kunal P. Patel · Translational Therapeutics (United States)

Michael T. Werner

Topics & Keywords

Immune Cell Function and Interaction Immunotherapy and Immune Responses T-cell and B-cell Immunology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Nature

Volume 571, Issue 7764, pp. 211-218

DOI: 10.1038/s41586-019-1325-x

Field-Weighted Citation Impact: 59.74

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion | Researchclopedia

· University of Pennsylvania

Alexander C. Huang · University of Pennsylvania

Katherine A. Alexander · University of Pennsylvania

Jennifer E. Wu · Translational Therapeutics (United States)

John Attanasio · University of Pennsylvania

Patrick Yan · University of Pennsylvania

Sangeeth M. George · Translational Therapeutics (United States)

Bertram Bengsch · University Medical Center Freiburg

Ryan P. Staupe · Translational Therapeutics (United States)

Greg Donahue · University of Pennsylvania

Wei Xu · University of Pennsylvania

Ravi K. Amaravadi · University of Pennsylvania

Xiaowei Xu · University of Pennsylvania

Giorgos C. Karakousis · University of Pennsylvania

Tara C. Mitchell · University of Pennsylvania

Lynn M. Schuchter · University of Pennsylvania

Jonathan Kaye · Cedars-Sinai Medical Center

Shelley L. Berger · University of Pennsylvania

E. John Wherry · University of Pennsylvania