The first Japanese nationwide multicenter study of BRCA mutation testing in ovarian cancer: CHARacterizing the cross-sectionaL approach to Ovarian cancer geneTic TEsting of BRCA (CHARLOTTE)

Patients with high-grade serous carcinoma and family history of ovarian cancer had a slightly higher prevalence of g<i>BRCA</i> mutations, but none of the subgroups had considerably high g<i>BRCA</i> mutation prevalence. These data suggest that g<i>BRCA</i> testing should be carried out in all patients with ovarian cancer.