Inhaled alprazolam rapidly suppresses epileptic activity in photosensitive participants

201946 citationsJournal Articlehybrid Open Access

Authors

Jacqueline A. French · New York University

Robert Wechsler · Family Medicine Residency of Idaho

Michael Gelfand · University of Pennsylvania

John R. Pollard · University of Pennsylvania

Blanca Vázquez · New York University

Daniel Friedman · New York University

Lily H. Gong ·

Abstract

This proof-of-concept study demonstrated that Staccato alprazolam 0.5, 1.0, and 2.0 mg rapidly suppressed epileptiform activity in photosensitive participants with epilepsy. The AE profile of Staccato alprazolam was similar to what has been reported for alprazolam for other indications. The results support further development of Staccato alprazolam as a rescue medication for the acute treatment of seizures.

Topics & Keywords

Epilepsy research and treatment Anesthesia and Sedative Agents Neuroscience and Neuropharmacology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Epilepsia

Volume 60, Issue 8, pp. 1602-1609

DOI: 10.1111/epi.16279

Field-Weighted Citation Impact: 3.78