Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis

201922 citationsJournal Articlegold Open Access

Authors

Nittaya Khakhum · The University of Texas Medical Branch at Galveston

Preeti Bharaj · The University of Texas Medical Branch at Galveston

Julia N. Myers · The University of Texas Medical Branch at Galveston

Daniel Tapia · The University of Texas Medical Branch at Galveston

David H. Walker · The University of Texas Medical Branch at Galveston

Janice J. Endsley · The University of Texas Medical Branch at Galveston

Abstract

Our data indicate that CLH001 serves as an effective live attenuated vaccine to prevent glanders and melioidosis. The quantity and quality of antibody responses as well as improving cell-mediated immune responses following vaccination need to be further investigated prior to advancement to preclinical studies.

Topics & Keywords

Burkholderia infections and melioidosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS neglected tropical diseases

Volume 13, Issue 7, pp. e0007578-e0007578

DOI: 10.1371/journal.pntd.0007578

Field-Weighted Citation Impact: 2.55