Targeting neurons in the gastrointestinal tract to treat Parkinson's disease

201943 citationsJournal Articlegold Open Access

Authors

Robert A. Hauser

Dean Sutherland · The Memory Clinic

Juan Antonio Madrid · Universidad de Murcia

María Ángeles Rol · Universidad de Murcia

Steven J. Frucht · NYU Langone Health

Stuart Isaacson · Parkinson's Research and Education Foundation

Fernando Pagán · Georgetown University

Abstract

Orally administered ENT-01 was safe and significantly improved bowel function in PD, suggesting that the ENS is not irreversibly damaged in PD. Minimal systemic absorption suggests that improvements result from local stimulation of the ENS. A double-blind, placebo-controlled study is now ongoing.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Nuclear Receptors and Signaling Neurological disorders and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Parkinsonism & Related Disorders

Volume 1, pp. 2-7

DOI: 10.1016/j.prdoa.2019.06.001

Field-Weighted Citation Impact: 3.13