Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

2019232 citationsJournal Articlebronze Open Access

Authors

Dimitrios Kapogiannis · National Institute on Aging

Maja Mustapić · National Institutes of Health

Michelle Shardell · National Institutes of Health

Sean T. Berkowitz · Institute on Aging

Thomas C. Diehl · National Institutes of Health

Ryan D. Spangler · Institute on Aging

Joyce Tran

Abstract

We validated nEV biomarker candidates and further demonstrated that their preclinical longitudinal trajectories can predict AD diagnosis. These findings motivate further development of nEV biomarkers toward a clinical blood test for AD.

Topics & Keywords

Extracellular vesicles in disease Air Quality and Health Impacts Cardiovascular Disease and Adiposity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Neurology

Volume 76, Issue 11, pp. 1340-1340

DOI: 10.1001/jamaneurol.2019.2462

Field-Weighted Citation Impact: 10.31