Methoxychalcones: Effect of Methoxyl Group on the Antifungal, Antibacterial and Antiproliferative Activities

201916 citationsJournal Articlegreen Open Access

Authors

Beatriz C. Marques · Universidade Estadual Paulista (Unesp)

Mariana Bastos dos Santos · Universidade Estadual Paulista (Unesp)

Daiane Bertholin Anselmo · Universidade Estadual Paulista (Unesp)

Diego Alves Monteiro · Universidade Estadual Paulista (Unesp)

Eleni Gomes · Universidade Estadual Paulista (Unesp)

Marilia F.C. Saiki · Universidade Estadual Paulista (Unesp)

Paula Rahal

Abstract

Our studies corroborated the relevance of methoxychalcones as antifungal, antibacterial and antiproliferative agents. In addition, we elucidated influence of the position and number of methoxyl groups toward bioactivity. In silico predictions indicated good drug-likeness and pharmacokinetics properties to the library of methoxychalcones.

Topics & Keywords

Synthesis and biological activity Multicomponent Synthesis of Heterocycles Synthesis and Biological Evaluation

Publication Details

Published in: Medicinal Chemistry

Volume 16, Issue 7, pp. 881-891

DOI: 10.2174/1573406415666190724145158

Field-Weighted Citation Impact: 0.45

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Methoxychalcones: Effect of Methoxyl Group on the Antifungal, Antibacterial and Antiproliferative Activities

Authors

Abstract

Topics & Keywords

Publication Details