Evaluation of HIV-1 integrase resistance emergence and evolution in patients treated with integrase inhibitors

201921 citationsJournal Articlehybrid Open Access

Authors

Rossana Scutari · University of Rome Tor Vergata

Claudia Alteri · University of Milan

Ilaria Vicenti · University of Siena

Domenico Di Carlo · University of Milan

Valentina Zuccaro · Policlinico San Matteo Fondazione

Francesca Incardona · Informa (Italy)

Vanni Borghi ·

Abstract

These findings confirm that major INSTI-RMs very rarely occur in INSTI-naïve patients. Under INSTI treatment, selection of drug-resistance follows the typical drug-resistance pathways; a higher evolution characterises integrase sequences developing drug-resistance compared with those without any resistance.

Topics & Keywords

HIV/AIDS drug development and treatment HIV Research and Treatment Biochemical and Molecular Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Global Antimicrobial Resistance

Volume 20, pp. 163-169

DOI: 10.1016/j.jgar.2019.07.015

Field-Weighted Citation Impact: 1.45