ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice

2019126 citationsJournal Articlehybrid Open Access

Authors

Weiguo Fan · Institut Pasteur of Shanghai

Tianhui Liu · Capital Medical University

Wen Chen · Institut Pasteur of Shanghai

Seddik Hammad · South Valley University

Thomas Longerich · Heidelberg University

Ingrid Haußer · Heidelberg University

Yadong Fu ·

Abstract

ECM1, produced by hepatocytes, inhibits activation of TGFB and its activation of HSCs to prevent fibrogenesis in mouse liver. Strategies to increase levels of ECM1 in liver might be developed for treatment of fibrosis.

Topics & Keywords

Liver physiology and pathology Liver Disease Diagnosis and Treatment Organ Transplantation Techniques and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gastroenterology

Volume 157, Issue 5, pp. 1352-1367.e13

DOI: 10.1053/j.gastro.2019.07.036

Field-Weighted Citation Impact: 6.76