6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers

201946 citationsJournal Articlebronze Open Access

Authors

Hailing Yang · The University of Texas MD Anderson Cancer Center

Shu Zhang · The University of Texas MD Anderson Cancer Center

Yongying Jiang · The University of Texas MD Anderson Cancer Center

Weiqun Mao · The University of Texas MD Anderson Cancer Center

Lan Pang · The University of Texas MD Anderson Cancer Center

Abena B. Redwood · The University of Texas MD Anderson Cancer Center

Abstract

PFKFB2 is a novel target whose inhibition can enhance the effect of paclitaxel-based primary chemotherapy upon ovarian and breast cancers retaining wt<i>TP53</i>.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Cancer-related Molecular Pathways Microtubule and mitosis dynamics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 25, Issue 18, pp. 5702-5716

DOI: 10.1158/1078-0432.ccr-18-3448

Field-Weighted Citation Impact: 2.37