Exosomes derived from mesenchymal stem cells reverse EMT via TGF-β1/Smad pathway and promote repair of damaged endometrium

2019283 citationsJournal Articlegold Open Access

Authors

Yuan Yao · First Affiliated Hospital of Shihezi University Medical College

Ran Chen · First Affiliated Hospital of Shihezi University Medical College

Guowu Wang · First Affiliated Hospital of Shihezi University Medical College

Yu Zhang · First Affiliated Hospital of Shihezi University Medical College

Abstract

BMSC-derived Exo is involved in the repair of injured endometrium, with similar effect to that of BMSC, and can reverse EMT in rabbit EECs induced by TGF-β1. BMSC-derived Exo may promote endometrial repair by the TGF-β1/Smad signaling pathway.

Topics & Keywords

Gynecological conditions and treatments Endometrial and Cervical Cancer Treatments Reproductive System and Pregnancy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

Volume 10, Issue 1, pp. 225-225

DOI: 10.1186/s13287-019-1332-8

Field-Weighted Citation Impact: 23.87