Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy

2019107 citationsJournal Articlegold Open Access

Authors

Liyuan Jin · Chinese People's Liberation Army

Zihui Deng · Chinese PLA General Hospital

Jinying Zhang · Chinese PLA General Hospital

Chen Yang · Chinese PLA General Hospital

Jiejie Liu · Chinese PLA General Hospital

Weidong Han · Chinese PLA General Hospital

Ping Ye ·

Abstract

Our results suggested that MSC infusions can protect against cardiac injury in DCM rats. The underlying mechanisms may include MSC-enhanced M2 macrophage polarization via the COX-2-PGE2 pathway.

Topics & Keywords

Cardiovascular Function and Risk Factors Mesenchymal stem cell research Cardiac Fibrosis and Remodeling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Translational Medicine

Volume 17, Issue 1, pp. 251-251

DOI: 10.1186/s12967-019-1999-8

Field-Weighted Citation Impact: 10.94