Association of CAG Repeats With Long-term Progression in Huntington Disease

201965 citationsJournal Articlebronze Open Access

Authors

Douglas R. Langbehn · University of Iowa

Julie C. Stout · Monash University

Sarah Gregory · Huntington's Disease Association

James A. Mills · University of Iowa

Alexandra Dürr · Inserm

Blair R. Leavitt · University of British Columbia

Raymund A.C. Roos ·

Abstract

Results of this study suggest that succinct summary measures of function and brain loss characterize HD progression across a wide disease span. CAG repeat length strongly predicts their decline rate. This work aids our understanding of the age and CAG repeat length-dependent association between changes in the brain and clinical manifestations of HD.

Topics & Keywords

Genetic Neurodegenerative Diseases Neurological disorders and treatments Mitochondrial Function and Pathology

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: JAMA Neurology

Volume 76, Issue 11, pp. 1375-1375

DOI: 10.1001/jamaneurol.2019.2368

Field-Weighted Citation Impact: 4.35