miR-19a-3p containing exosomes improve function of ischaemic myocardium upon shock wave therapy

2019105 citationsJournal Article

Authors

Can Gollmann‐Tepeköylü · Universität Innsbruck

Leo Pölzl · Austrian Cluster for Tissue Regeneration

Michael Graber · Innsbruck Medical University

Jakob Hirsch · Austrian Cluster for Tissue Regeneration

Felix Nägele · Austrian Cluster for Tissue Regeneration

Daniela Lobenwein · Innsbruck Medical University

Michael W. Hess

Abstract

The mechanical stimulus of SWT causes release of angiogenic exosomes. miR-19a-3p is the vesicular cargo responsible for the observed effects. Released exosomes induce angiogenesis, decrease myocardial fibrosis, and improve left ventricular function after myocardial ischaemia. Exosome release via SWT could develop an innovative approach for the regeneration of ischaemic myocardium.

Topics & Keywords

Cardiovascular Effects of Exercise Heat shock proteins research Cardiac Ischemia and Reperfusion

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cardiovascular Research

Volume 116, Issue 6, pp. 1226-1236

DOI: 10.1093/cvr/cvz209

Field-Weighted Citation Impact: 9.33