Analysis of Vibrio cholerae genomes identifies new type VI secretion system gene clusters

201970 citationsJournal Articlegold Open Access

Authors

Cristian V. Crisan · Georgia Institute of Technology

Aroon T. Chande · Georgia Institute of Technology

Kenneth C. Williams · Georgia Institute of Technology

Vishnu Raghuram · Georgia Institute of Technology

Lavanya Rishishwar · Georgia Institute of Technology

Gabi Steinbach · Georgia Institute of Technology

Samit S. Watve

Abstract

We develop a novel bioinformatics method and identify new T6SS gene clusters in V. cholerae. We also show the TleV1 toxin is delivered in a T6SS manner by V. cholerae and can lyse other bacterial cells. Our web-based tool can be modified to identify additional novel T6SS genomic loci in diverse bacterial species.

Topics & Keywords

Vibrio bacteria research studies Antibiotic Resistance in Bacteria Escherichia coli research studies

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Genome biology

Volume 20, Issue 1, pp. 163-163

DOI: 10.1186/s13059-019-1765-5

Field-Weighted Citation Impact: 6.10