Therapeutic inhibition of microRNA-34a ameliorates aortic valve calcification via modulation of Notch1-Runx2 signalling

201958 citationsJournal Article

Authors

Taku Toshima · Yamagata University

Tetsu Watanabe · Yamagata University

Taro Narumi · Yamagata University

Yoichiro Otaki · Yamagata University

Tetsuro Shishido · Yamagata University

Tomonori Aono · Yamagata University

Jun Goto · Yamagata University

Abstract

miR-34a plays an important role in the development of CAVS via Notch1-Runx2 signalling pathway. Inhibition of miR-34a may be the therapeutic target for CAVS.

Topics & Keywords

Cardiac Valve Diseases and Treatments Aortic Disease and Treatment Approaches MicroRNA in disease regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cardiovascular Research

Volume 116, Issue 5, pp. 983-994

DOI: 10.1093/cvr/cvz210

Field-Weighted Citation Impact: 5.15