Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis

2019151 citationsJournal Articlegold Open Access

Authors

Aadya Nagpal · La Trobe University

Richard P. Redvers · La Trobe University

Xiawei Ling · Peter MacCallum Cancer Centre

Scott Ayton · Florey Institute of Neuroscience and Mental Health

Miriam Fuentes · La Trobe University

Elnaz Tavancheh · La Trobe University

Irmina Diala ·

Abstract

The TBCP-1 model recapitulates the spontaneous spread of HER2-positive breast cancer to the brain seen in patients and provides a unique tool to identify novel therapeutics and biomarkers. Neratinib-induced ferroptosis provides new opportunities for therapeutic intervention. Further evaluation of neratinib neoadjuvant therapy is warranted.

Topics & Keywords

Ferroptosis and cancer prognosis Cancer-related gene regulation Lung Cancer Treatments and Mutations

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Breast Cancer Research

Volume 21, Issue 1, pp. 94-94

DOI: 10.1186/s13058-019-1177-1

Field-Weighted Citation Impact: 11.71