Replicated methylation changes associated with eczema herpeticum and allergic response

201929 citationsJournal Articlegold Open Access

Authors

Meher Preethi Boorgula · University of Colorado Denver

Margaret A. Taub · Johns Hopkins University

Nicholas Rafaels · University of Colorado Denver

Michelle Daya · University of Colorado Denver

Monica Campbell · University of Colorado Denver

Sameer Chavan · University of Colorado Denver

Aniket Shetty

Abstract

We identified a CpG in IL4 associated with serum tIgE levels, supporting a role for Th2 immune mediating mechanisms in AD. Changes in eosinophil level, a measure of disease severity, are associated with methylation changes, providing a potential mechanism for phenotypic changes in immune response-related traits.

Topics & Keywords

IL-33, ST2, and ILC Pathways Asthma and respiratory diseases Dermatology and Skin Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Epigenetics

Volume 11, Issue 1, pp. 122-122

DOI: 10.1186/s13148-019-0714-1

Field-Weighted Citation Impact: 1.57