STAT3 phosphorylation mediates the stimulatory effects of interferon alpha on B cell differentiation and activation in SLE

201921 citationsJournal Articlebronze Open Access

Authors

Aurélie De Groof · UCLouvain

Julie Ducreux · UCLouvain

Floor Aleva · Radboud University Nijmegen

Andrew J. Long · AbbVie (United States)

Alina Ferster · Queen Fabiola Children's University Hospital

André van der Ven · Radboud University Nijmegen

Frank L. van de Veerdonk ·

Abstract

IFNα displays direct stimulatory effects on B cell differentiation and activation in SLE. STAT3 phosphorylation mediates the effects of IFNα stimulation in naïve B cells, an observation that opens new therapeutic perspectives in SLE.

Topics & Keywords

Immune Cell Function and Interaction T-cell and B-cell Immunology Chronic Lymphocytic Leukemia Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Lara D. Veeken

Volume 59, Issue 3, pp. 668-677

DOI: 10.1093/rheumatology/kez354

Field-Weighted Citation Impact: 1.14