Genome‐wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

2019175 citationsJournal Articlebronze Open Access

Authors

Sonia Moreno–Grau · Instituto de Salud Carlos III

Itziar de Rojas · Fundació ACE

Isabel Hernández · Instituto de Salud Carlos III

Inés Quintela · Instituto de Salud Carlos III

Laura Montrreal · Fundació ACE

Montserrat Alegret · Centro Andaluz de Biología del Desarrollo

Begoña Hernández‐Olasagarre

Abstract

The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series.

Topics & Keywords

Alzheimer's disease research and treatments Genetic Associations and Epidemiology Bioinformatics and Genomic Networks

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia

Volume 15, Issue 10, pp. 1333-1347

DOI: 10.1016/j.jalz.2019.06.4950

Field-Weighted Citation Impact: 10.33