Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells

2019102 citationsJournal Articlegold Open Access

Authors

Yanju Wu · China Medical University

Qianqian Zheng · China Medical University

Yan Li · China Medical University

Guang Wang · China Medical University

Shuting Gao · China Medical University

Xiaodong Zhang · Fourth Affiliated Hospital of China Medical University

Xu Yan ·

Abstract

The results of our study reveal a new potential regulatory pathway in which metformin inhibits cell proliferation via AMPKα/Yap1/TEAD4/CCNE1/2 axis in BLCA cells, providing new insights into novel molecular therapeutic targets for BLCA.

Topics & Keywords

Hippo pathway signaling and YAP/TAZ Cancer-related Molecular Pathways Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Experimental & Clinical Cancer Research

Volume 38, Issue 1, pp. 376-376

DOI: 10.1186/s13046-019-1346-1

Field-Weighted Citation Impact: 7.49