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Clarification of fermentation broths is one of the most important and disregarded steps in biotech processes. The first purification step after fermentation is the cell removal from several ml up to thousand l culture broth. Alluvial or cake filtration, e.g. diatomaceous earth filtration, is a well-established method in pharmaceutical industries. Depth filters are in the retention rate range of 50-0.04 nominal filters. They are mainly made from cellulose fibers, a porous filter aid and a positively charged polymeric resin binder. DAISEP MabXpure is a filtering aid technology developed to improve the performance of clarification steps. DAISEP MabXpure massively removes HCP, DNA, and other impurities, with high yield of IgG. The use of filter aid over depth filter media modules is a concept, which fits perfectly with the trend for the use of disposables in bioprocessing.