PP.40.21

Objective: The aim of the study is to investigate the prevalence of resistant hypertension in specialized consultation in the area of Blida (Algeria), to assess the causes of resistant hypertension and clinical parameters characterizing this condition. Design and method: A total of 2175 hypertensive patients treated of both sexes were included (1158 females and 1017 males) with a mean age of 49.71 ± 13.56 years, examined between June 2012-june 2014. The control consisted of filling a questionnaire oriented on civil status, medical history, anthropometric parameters, and routine blood exams were collected. Resistant hypertension was identified according to the following criteria: office blood pressure that remains above goal in spite of the concurrent use of 3 antihypertensive agents of different classes, including a diuretic, at full dose. All calculations and statistical analyzes are processed by the SPSS 17.0. Results: 413 patients (19%) resulted to be resistant to antihypertensive treatment. Among resistant hypertensive patients the following conditions were significantly more represented: older age (65.7 ± 12.6 vs 57.7 ± 13.4 years, p < 0.001), sedentary status (87.1 vs 74.5% p < 0.05), previous cardiovascular events (36.9 vs 17.7%, p < 0.001), diabetes (41.8 vs 26.5%, p < 0.001), hypercholesterolemia (20.8 vs 11.4%, p < 0.05), obesity (35.5 vs 16.3%, p < 0.0001), metabolic syndrome (48.2 vs 22.6%, p < 0.03), chronic kidney disease (24.9 vs 14.1%, p < 0.05). In a logistic regression model adjusted for confounders, only metabolic syndrome and diabetes mellitus (p = 0.002) were associated to an increased probability to have resistant hypertension. Conclusions: All classical cardiovascular risk factors were more frequent in resistant hypertensive patients; only metabolic syndrome and diabetes mellitus were independently associated with this condition.