Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering

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Authors

Stanislav A. Evlashin · Skolkovo Institute of Science and Technology

Pavel V. Dyakonov · Skolkovo Institute of Science and Technology

Mikhail Tarkhov · Russian Academy of Sciences

Sarkis A. Dagesyan · Lomonosov Moscow State University

Sergei A. Rodionov · Central Scientific Research Institute of Traumatology and Orthopedics

Anastasia Shpichka · Sechenov University

M. O. Kostenko

Abstract

Developing bone scaffolds can greatly improve the patient's quality of life by accelerating the rehabilitation process. In this paper, we studied the process of composite polycaprolactone supercritical foaming for tissue engineering. The influence of graphene oxide and reduced graphene oxide on the foaming parameters was studied. The structural and mechanical properties were studied. The scaffolds demonstrated mechanical flexibility and endurance. The co-culturing and live/dead tests demonstrated that the obtained scaffolds are biocompatible. Different composite scaffolds induced various surface cell behaviors. The experimental data demonstrate that composite foams are promising candidates for in vivo medical trials.

Topics & Keywords

Polymer Foaming and Composites Graphene and Nanomaterials Applications Orthopaedic implants and arthroplasty

UN Sustainable Development Goals

Industry, innovation and infrastructure

Publication Details

Published in: Materials

Volume 12, Issue 18, pp. 2991-2991

DOI: 10.3390/ma12182991

Field-Weighted Citation Impact: 3.83