Vemurafenib for Refractory Multisystem Langerhans Cell Histiocytosis in Children: An International Observational Study

2019215 citationsJournal Articlehybrid Open Access

Authors

Jean Donadieu

Islam Amine Larabi

M. Tardieu · Centre Hospitalier Universitaire de Grenoble

Johannes Visser · Cambridge University Hospitals NHS Foundation Trust

Caroline Hutter · Medical University of Vienna

Elena Sieni · Meyer Children's Hospital

Nabil Kabbara · Rafik Hariri University Hospital

Mohamed Barkaoui

Abstract

VMF seemed safe and effective in children with refractory <i>BRAF<sup>V600E</sup></i>-positive LCH. Additional studies are needed to find effective maintenance therapy approaches.

Topics & Keywords

Histiocytic Disorders and Treatments Viral-associated cancers and disorders Vascular Malformations and Hemangiomas

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 37, Issue 31, pp. 2857-2865

DOI: 10.1200/jco.19.00456

Field-Weighted Citation Impact: 12.66