The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse

2019136 citationsJournal Articlehybrid Open Access

Authors

Stefano Toldo · Children's Hospital of Richmond at VCU

Adolfo G Mauro · Children's Hospital of Richmond at VCU

Zachary Cutter · Children's Hospital of Richmond at VCU

Benjamín Van Tassell · Virginia Commonwealth University

Eleonora Mezzaroma

Marco Giuseppe Del Buono · Children's Hospital of Richmond at VCU

Andrea Prestamburgo · Children's Hospital of Richmond at VCU

Abstract

OLT1177 (dapansutrile) limits infarct size and prevents left ventricular systolic dysfunction when given within 60 minutes following ischemia reperfusion injury in the mouse.

Topics & Keywords

Cardiac Ischemia and Reperfusion Anesthesia and Neurotoxicity Research Mitochondrial Function and Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Cardiovascular Pharmacology

Volume 73, Issue 4, pp. 215-222

DOI: 10.1097/fjc.0000000000000658

Field-Weighted Citation Impact: 10.71