Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

2019135 citationsJournal Articlebronze Open Access

Authors

Takuto Chiba · Children's Hospital of Pittsburgh

Kevin Peasley · Children's Hospital of Pittsburgh

Kasey R. Cargill · Children's Hospital of Pittsburgh

Katherine Maringer · Children's Hospital of Pittsburgh

Sivakama S. Bharathi · Children's Hospital of Pittsburgh

Elina Mukherjee · Children's Hospital of Pittsburgh

Yuxun Zhang

Abstract

Our findings indicate that Sirt5 regulates the balance of mitochondrial versus peroxisomal fatty acid oxidation in proximal tubular epithelial cells to protect against injury in AKI. This novel mechanism might be leveraged for developing AKI therapies.

Topics & Keywords

Acute Kidney Injury Research Heme Oxygenase-1 and Carbon Monoxide Cardiac Ischemia and Reperfusion

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Journal of the American Society of Nephrology

Volume 30, Issue 12, pp. 2384-2398

DOI: 10.1681/asn.2019020163

Field-Weighted Citation Impact: 9.14