High-Intensity Focused Ultrasound (HIFU) Triggers Immune Sensitization of Refractory Murine Neuroblastoma to Checkpoint Inhibitor Therapy

2019164 citationsJournal Articlegreen Open Access

Authors

Avinash Eranki · Children's National

Priya Srinivasan · Children's National

Mario Ries · Utrecht University

AeRang Kim · Children's National

Christopher A. Lazarski · Children's National

Christopher Rossi · Children's National

Tatiana D. Khokhlova ·

Abstract

Mechanical fractionation of tumors using HIFU can effectively induce immune sensitization in a previously unresponsive murine neuroblastoma model and promises a novel yet efficacious immunoadjuvant modality to overcome therapeutic resistance.

Topics & Keywords

Neuroblastoma Research and Treatments Cancer Immunotherapy and Biomarkers Cancer Research and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 26, Issue 5, pp. 1152-1161

DOI: 10.1158/1078-0432.ccr-19-1604

Field-Weighted Citation Impact: 9.71