Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade

2019714 citationsJournal Article

Authors

Imran G. House · The University of Melbourne

Peter Savas · The University of Melbourne

Junyun Lai · The University of Melbourne

Amanda X. Y. Chen · The University of Melbourne

Amanda J. Oliver · The University of Melbourne

Zhi L. Teo · The University of Melbourne

Kirsten L. Todd ·

Abstract

These data underline the fundamental importance of macrophage-derived CXCR3 ligands for the therapeutic efficacy of ICB and highlight the potential of manipulating this axis to enhance patient responses.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses Immune Cell Function and Interaction

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 26, Issue 2, pp. 487-504

DOI: 10.1158/1078-0432.ccr-19-1868

Field-Weighted Citation Impact: 23.65