Galectin-1 induces metastasis and epithelial-mesenchymal transition (EMT) in human ovarian cancer cells via activation of the MAPK JNK/p38 signalling pathway.

201965 citationsJournal Articlegreen Open Access

Authors

Jie Zhu · Obstetrics and Gynecology Hospital of Fudan University

Ya Zheng

Abstract

Gal-1 enhances metastasis and EMT of ovarian cancer cells via promoting the activation of the MAPK JNK/p38 signalling pathway, suggesting the possibility that Gal-1 is a molecular target to prevent and cure ovarian cancer metastasis.

Topics & Keywords

Galectins and Cancer Biology Toxin Mechanisms and Immunotoxins Signaling Pathways in Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 11, Issue 6, pp. 3862-3878

Field-Weighted Citation Impact: 4.00