Cancer Risks Associated With Germline<i>PALB2</i>Pathogenic Variants: An International Study of 524 Families

These results confirm <i>PALB2</i> as a major breast cancer susceptibility gene and establish substantial associations between germline <i>PALB2</i> PVs and ovarian, pancreatic, and male breast cancers. These findings will facilitate incorporation of <i>PALB2</i> into risk prediction models and optimize the clinical cancer risk management of <i>PALB2</i> PV carriers.