Common DNA sequence variation influences 3-dimensional conformation of the human genome

201992 citationsJournal Articlegold Open Access

Authors

David U. Gorkin · Ludwig Cancer Research

Yunjiang Qiu · University of California, San Diego

Ming Hu · Cleveland Clinic

Kipper Fletez‐Brant · Johns Hopkins Medicine

Tristin Liu · Ludwig Cancer Research

Anthony D. Schmitt · Arima Genomics (United States)

Amina Noor ·

Abstract

Our results demonstrate that common DNA sequence variants can influence 3D chromatin conformation, pointing to a more pervasive role for 3D chromatin conformation in human phenotypic variation than previously recognized.

Topics & Keywords

Genomics and Chromatin Dynamics Epigenetics and DNA Methylation RNA Research and Splicing

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 20, Issue 1, pp. 255-255

DOI: 10.1186/s13059-019-1855-4

Field-Weighted Citation Impact: 5.05