Epigenetic Regulation of m6A Modifications in Human Cancer

N6-methyladenosine (m⁶A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m⁶A modifications of RNA regulate splicing, translocation, stability, and translation into proteins. m⁶A modifications are catalyzed by RNA methyltransferases, such as METTL3, METTL14, and WTAP (writers); the modifications are removed by the demethylases fat mass and obesity-associated protein (FTO) and ALKBH5 (ALKB homolog 5) (erasers); and the modifications are recognized by m⁶A-binding proteins, such as YTHDF domain-containing proteins and IGF2BPs (readers). Abnormal changes in the m⁶A levels of these genes are closely related to tumor occurrence and development. In this paper, we review the role of m⁶A in human cancer and summarize its prospective applications in cancer.